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Furosemide is a loop diuretic used in the treatment of congestive heart failure and edema. Furosemide is most commonly marketed by Sanofi-Aventis under the brand name Lasix. Furosemide has also been used to prevent thoroughbred and standard bred race horses from bleeding through the nose during races. Along with some other diuretics, Furosemide is also included on the World Anti-Doping Agency's banned drug list due to its alleged use as a masking agent for other drugs. Buy Furosemide with no prescription.

Like other loop diuretics, Furosemide acts by inhibiting the Na-K-2Cl symporter in the thick ascending limb of the loop of Henle. The action on the distal tubules is independent of any inhibitory effect on carbonic anhydrate or aldosterone.
Additionally, Furosemide is a noncompetitive subtype-specific blocker of GABA-A receptors. Furosemide has been reported to reversibly antagonize GABA-evoked currents of alpha6 beta2 gamma2 receptors at microM concentrations, but not alpha1 beta2 gamma2 receptors. During development, the alpha6 beta2 gamma2 receptor increases in expression in cerebellar granule neurons, corresponding to increased sensitivity to Furosemide.

Furosemide is principally used in the following indications:

- Edema associated with heart failure, hepatic cirrhosis, renal impairment, nephritic syndrome
- Adjunct in cerebral/pulmonary edema where rapid diuresis is required
- Hypertension

Furosemide is also used in the management of severe hypocalcaemia in combination with adequate rehydration.

Furosemide is injected either intramuscularly or intravenously, usually 0.5-1.0 mg/kg 2x/day, although less before a horse is raced. As with many diuretics, Furosemide can cause dehydration and electrolyte imbalance, including loss of potassium, calcium, sodium, and magnesium. Excessive use of Furosemide will most likely lead to a metabolic alkalosis due to hypochloremia and hypokalemia as well as retention of bicarbonate as a result of fluid volume loss. Overdose may lead to dehydration, change in drinking patterns and urination, seizures, GI problems, kidney damage, lethargy, collapse, and coma.
Furosemide should be used with caution when combined with corticosteroids, amino glycoside, and trimethoprim. Furosemide may also cause interactions with anesthesics, so its use should be related to the veterinarian if the animal is going into surgery, and it decreases the kidney's ability to excrete aspirin, so dosages will need to be adjusted if combined with that drug
Furosemide is detectible in urine 36-72 hours following injection.